Familial Hypercholesterolaemia
Familial Hypercholesterolaemia (FH) is a common, inherited genetic disorder that causes very high levels of “bad” cholesterol (LDL-C) from birth. Unlike high cholesterol caused by diet or lifestyle, FH is present regardless of your lifestyle, significantly increasing your risk of developing premature cardiovascular disease, such as heart attacks or strokes, at a much younger age. Early diagnosis and management are crucial to prevent these serious complications.
Treatment Options
Lifestyle modifications
While FH is genetic, a heart-healthy diet, regular exercise, maintaining a healthy weight, and avoiding smoking are still important to support overall cardiovascular health.
Family screening
As FH is genetic, we recommend screening close family members to identify others who may be affected and benefit from early treatment.
Medication
High-dose statins are the first-line treatment. Other medications like ezetimibe, PCSK9 inhibitors, or bempedoic acid may be added or used if statins aren't tolerated or are insufficient.
Frequently Asked Questions
Is FH preventable?
No, FH is inherited, so it cannot be prevented. However, its effects can be managed effectively with early diagnosis and treatment.
Do I need to change my diet?
While diet isn’t the cause of FH, adopting a heart-healthy diet low in saturated and trans fats is still beneficial for overall cardiovascular health.
Will my children get FH?
If you have FH, each of your children has a 50% chance of inheriting the condition. Genetic testing and screening are recommended.
How often do I need to see a cardiologist?
This will depend on your specific condition, but regular follow-up appointments are essential for monitoring your cholesterol levels and heart health.